Schools and early care and education (ECE) programs are an important part of the infrastructure of communities. They provide safe, supportive learning environments for children and adolescents and employ teachers and other staff.1, 2 Schools and some ECE programs also provide critical services, including school meal programs and social, physical, behavioral, and mental health services.1, 3 Schools and ECE programs have other benefits for the community, including enabling parents, guardians, and caregivers to work.1, 2, 4 In the spring of 2020, kindergarten to grade 12 (K-12) schools and many ECE programs in the United States closed for in-person instruction or care as a strategy to slow the spread of SARS-CoV-2, the virus that causes COVID-19. Reports suggest that the limited in-person instruction during the pandemic may have had a negative effect on learning for children5 and on the mental and emotional well-being of both parents and children.6, 7 For schools and ECE programs, the benefits of in-person school and caregiving need to be balanced against the risk of acquiring and spreading SARS-CoV-2 in these settings.